Dr. Lange is a Professor of Medicine (Division of Hematology, Oncology, and Transplantation) and Pharmacology and the Associate Director for Basic Science at the University of Minnesota Masonic Cancer Center. Her research is focused on the role of steroid hormone receptors (SRs) in breast and ovarian cancer. Estrogen receptors (ER) and progesterone receptors (PR) are context-dependent transcription factors that are important for normal breast development during puberty and pregnancy. These receptors, when abnormally activated, contribute to breast cancer biology and can dramatically influence responses to breast cancer therapies. An additional research focus is on closely related glucocorticoid receptors (GR) and their cross talk with stress-activated protein kinase signaling pathways and mineralocorticoid receptors (MR) in breast, ovarian, and pancreatic cancers. Targeting multiple signaling molecules in addition to SRs is predicted to halt cancer progression, prevent recurrence, and increase patient survival. Dr. Lange has over 30 years of experience in mechanisms of signal transduction related to cancer biology and altered cell fate, and the regulation of proteins by post-translational modifications. She has routinely developed new reagents and employed biochemistry and modern cell and molecular biology techniques as well as NextGen approaches to study the mechanisms of hormone action and altered gene regulation related to cancer biology and advanced tumor progression. As a leading scientist focused on hormones and cancer, and in her leadership roles within the Masonic Cancer Center, she has mentored >35 PhD and postdoctoral trainees as well as numerous junior faculty members. Dr. Lange promotes and supports trainee/early career development in a support learning environment that fosters creativity and independence of thought and that values collaboration and collegial interactions.