Sarat Chandarlapaty, MD, PhD

Professor of Medicine, Memorial Sloan Kettering Cancer Center, USA

Dr. Sarat Chandarlapaty is an Professor of Medicine at Memorial Sloan Kettering Cancer Center with appointments as a Laboratory Head in the Human Oncology and Pathogenesis Program and Member on the Breast Cancer Medicine Service. The goal of Dr. Chandarlapaty’s research is to investigate the mechanisms and consequences of activation of growth factor and hormonal signaling pathways in breast cancer and translate those findings towards the development of more effective and durable treatments for metastatic disease. A major focus of his laboratory has been to characterize the significance of alterations present in breast tumors that have progressed on targeted therapy.

Through these efforts he has helped to elucidate both immediate and delayed adaptations in breast cancers that promote treatment resistance. His laboratory has demonstrated how relief of negative feedback on receptor tyrosine kinases promotes adaptive resistance to PI3K pathway directed therapy, identified mutations in the ESR1 gene as a major acquired mechanism of resistance to hormonal therapies, and characterized how CDK6 upregulation overcomes clinically available CDK4/6 kinase inhibitors.